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GCSE Combined Science

Inheritance, Variation & Evolution

104 questions8 subtopicsAQAEdexcelEduqasOCRWJEC
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What's covered

Classification (Edexcel)14
Genetic Engineering14
Inheritance14
DNA and the Genome13
Inherited Diseases13
Variation13
Natural Selection and Evolution12
Speciation11

Key facts

1

A scientific name consists of two parts: the genus and the species.

2

In DNA, A pairs with T and C pairs with G.

3

Genetic engineering does raise ethical concerns — modified genes can spread, e.g. through cross-pollination — so the claim "no ethical concerns" is false.

4

A carrier of a recessive disease has one disease allele but shows no symptoms (heterozygous, e.g. Ff for cystic fibrosis).

5

Cystic fibrosis is autosomal recessive because it is caused by a recessive allele on a non-sex chromosome (CFTR on chromosome 7).

6

Antibiotic resistance in bacteria is a modern example of natural selection: resistant bacteria survive antibiotic exposure and pass on the resistance gene.

7

Allopatric speciation involves three steps: isolation, different selection pressures, then genetic divergence.

8

Continuous variation shows a smooth range of values with no distinct categories — e.g. height, mass.

9

Linnaeus is credited with creating the binomial naming system.

10

Chromosomes are the structures inside the nucleus that carry the DNA molecules.

Sample questions

A taste of the 104 questions in this topic — answers marked. Sign up to practise the full set with spaced repetition.

1Classification (Edexcel)

Who proposed the five-kingdom classification system?

  • Carl Linnaeus
  • Carl Woese
  • Charles Darwin
  • Robert Whittaker
2DNA and the Genome

What is a gene?

  • A chromosome found only in body cells, never in gametes.
  • A section of DNA that codes for a specific protein.
  • A sequence of amino acids that forms one specific protein.
  • The complete set of DNA contained in a single cell.
3Genetic Engineering

What is a GM crop?

  • Crop bred over many generations
  • Crop given mineral supplements
  • Crop sprayed with growth hormone
  • Crop with altered DNA for improved traits
4Inheritance

In a cross between two heterozygous tall plants (Tt × Tt), what is the expected ratio of tall to short offspring?

  • 1 tall : 1 short
  • 1 tall : 3 short
  • 3 tall : 1 short
  • All tall plants
5Inherited Diseases

Why is cystic fibrosis autosomal recessive?

  • Autosomal recessive means dominant alleles on the sex chromosome.
  • Caused by a recessive allele on a non-sex chromosome.
  • It is caused by an extra chromosome rather than a faulty gene.
  • It only affects people with type A blood — carriers differ.
6Natural Selection and Evolution

What is natural selection?

  • Humans artificially breed organisms to select desirable traits each generation.
  • Organisms actively choose strongest mates to give offspring those traits.
  • Organisms with advantageous traits survive and pass them on.
  • Random DNA mutation improves survival in every environment automatically.

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